New Publication: Improved detection of colibactin-induced mutations by genotoxic E. coli in organoids and colorectal cancer

Co-culture of intestinal organoids with a colibactin-producing pks+ E. coli strain (EcC) revealed mutational signatures also found in colorectal cancer (CRC).

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PhD defence Flavia Peci

Just before Christmas on December 21st, our PhD student Flavia Peci defended her thesis "Genomic Safety of Transplantation; characterising the Mutational Consequences of Treatment in Hematopoietic Stem Cells".

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PhD Defence Eline Bertrums

Tuesday our PhD student Eline Bertrums defended her thesis defence entitled: "The Clonal Dynamics underlying the genesis and regression of myeloid disorders", with cum laude.

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New publication: COMPREHENSIVE SINGLE-CELL GENOME ANALYSIS AT NUCLEOTIDE RESOLUTION USING THE PTA ANALYSIS TOOLBOX

In our lab we developed the computational PTA Analysis Toolbox (PTATO) that can effectively filter artifacts from PTA-based WGS data, enabling accurate analyses of somatic mutations in single cells at nucleotide resolution.

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New Publication: Mutation accumulation in mtDNA of cancers resembles mutagenesis in normal stem cells

Mitochondria in normal cells accumulate mutations with age. Most mitochondrial mutations in cancer result from healthy mutation accumulation. Cancer therapies do not result in many mitochondrial mutations

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Ruben van Boxtel receives prestigious NYSCF Robertson Stem Cell Investigator Award

Today the NYSCF Robertson Stem Cell Investigator Award was awarded in New York today to Dr. Ruben van Boxtel. Van Boxtel, will use the award to accelerate his research on the role of stem cells in the development and eventual prevention of adverse late effects in children cured of cancer.

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Weekend van de Wetenschap 2022

Vind hier de presentatie van Ruben tijdens het Weekend van de Wetenschap 2022.

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Jurrian de Kanter wins "CS&D best publication of the year" award

Each year, the graduate school Cancer, Stem cells and Developmental biology gives an award to the PhD student with the best publication of that year. Today, the award was given to Jurrian de Kanter from our group for his two publications on the damaging effects of treatment in children with cancer.

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Now published in Cancer Discovery

Elevated mutational age in blood of children treated for cancer contributes to therapy-related myeloid neoplasms

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Karlijn defends her PhD thesis

"The beginning of a new life: characterising somatic mutation accumulation in fetal stem cells"

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New publication in STAR protocols!

Whole-genome sequencing and mutational analysis of human cord-blood derived stem and progenitor cells

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Proefdiervrij Venture Challenge

During a 3 months-long program six teams were guided through setting up a venture plan, which takes an animal free scientific breakthrough in the life sciences and transformed it into a solid business case.

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