Sjors Middelkamp

DNA damage can lead to mutations in the genome if it’s improperly repaired. These mutations can be at the basis of cancer formation. DNA can be damaged by exogenous sources such as radiation or chemicals. However, more often it’s damaged by endogenous, cell intrinsic sources, for example during DNA replication. I’m interested in how DNA damage caused by endogenous sources is repaired by cells and how it can lead to the formation of mutations, ultimately contributing to cancer evolution.