Annina Roelofsen
MSc Student

Cells are constantly exposed to DNA damage from outside and inside factors and DNA repair systems are important to correct this damage. However, if these systems do not function correctly it could contribute to an increased cancer risk. In XPC related syndromes the DNA repair does not function correctly, and an increased mutational rate has been observed, but the underlying mechanisms are still unclear. The aim of my project is to set up a model to mimic the XPC deficiency found in patients and which we then can use to look at the underlying mechanisms that causes the increased mutation rate observed in patients.